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USP13 promotes the development and metastasis of high-grade serous ovarian carcinoma in a novel mouse model. Kwon J, Choi H, Ware DA, Morillo BC, Wang H, Bouker KB, Lu X, Waldman T, Han C. Oncogene (2022). https://doi.org/10.1038/s41388-022-02224-x
Targeting DDX3X triggers anti-tumor immunity via a dsRNA-mediated tumor-intrinsic type I interferon response. Choi H, Kwon J, Cho MS, Sun Y, Zheng X, Wang J, Bouker KB, Casey JL, Atkins MB, Toretsky J, Han C. Cancer Res. 2021 May 3:canres.3790.2020. doi: 10.1158/0008-5472.CAN-20-3790. PMID: 33941613
USP13 interacts with cohesin and regulates its ubiquitination in human cells. He X, Kim JS, Diaz-Martinez L, Han C, Lane WS, Budnik B, Waldman T. J Biol Chem. 2020 Dec 17;296:100194. PMID: 33334891.
Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer. Liu Y, Xu J, Choi HH, Han C, Fang Y, Li Y, Van der Jeught K, Xu H, Zhang L, Frieden M, Wang L, Eyvani H, Sun Y, Zhao G, Zhang Y, Liu S, Wan J, Huang C, Ji G, Lu X, He X, Zhang X. Nat Commun. 2018 Nov 9;9(1):4718. PMID: 30413718.
Regulation of protein metabolism in cancer. Han C, Lu X, Nagrath D. Mol Cell Oncol. 2018 May 10;5(5):e1285384. PMID: 30263935.
Amplification of USP13 drives ovarian cancer metabolism. Han C, Yang L, Choi HH, Baddour J, Achreja A, Liu Y, Li Y, Li J, Wan G, Huang C, Ji G, Zhang X, Nagrath D, Lu X. Nat Commun. 2016 Nov 28;7:13525. PMID: 27892457.
TP53 loss creates therapeutic vulnerability in colorectal cancer. Liu Y, Zhang X, Han C, Wan G, Huang X, Ivan C, Jiang D, Rodriguez-Aguayo C, Lopez-Berestein G, Rao PH, Maru DM, Pahl A, He X, Sood AK, Ellis LM, Anderl J, Lu X. Nature. 2015 Apr 30;520(7549):697-701. PMID: 25901683.
The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression. Han C, Liu Y, Wan G, Choi HJ, Zhao L, Ivan C, He X, Sood AK, Zhang X, Lu X. Cell Rep. 2014 Sep 11;8(5):1447-60. PMID: 25176654